Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression-Reference-Cited by-同舟云学术

Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression

Published:2019-07-12 Issue:10 Volume:20 Page:1018-1028
ISSN:1389-4501
Container-title:Current Drug Targets
language:en
Short-container-title:CDT

Author:

Li Jun-Chen¹,Chang Xing²,Chen Yang²,Li Xin-Zhe²,Zhang Xiang-Lian³,Yang Shi-Ming²,Hu Chang-Jiang²,Zhang Hao¹

Affiliation:

1. Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

2. Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China

3. Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China

Abstract

HACE1 belongs to the family of HECT domain-containing E3 ligases, which plays an important role in the occurrence, invasion and metastatic process in many human malignancies. HACE1 is a tumor suppressor gene that is reduced in most cancer tissues compared to adjacent normal tissue. The loss or knocking out of HACE1 leads to enhanced tumor growth, invasion, and metastasis; in contrast, the overexpression of HACE1 can inhibit the development of tumors. Hypermethylation reduces the expression of HACE1, thereby promoting tumor development. HACE1 can inhibit the development of inflammation or tumors via the ubiquitination pathway. Therefore, HACE1 may be a potential therapeutic target, providing new strategies for disease prevention and treatment.

Funder

Frontier and Applied Basic Research Project of Chongqing Science and Technology Commission

National Natural Science Foundation of China (NSFC)

Publisher

Bentham Science Publishers Ltd.

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine

Reference118 articles.

1. Zhang L, Anglesio MS, O’Sullivan M. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.

2. Chen YL, Li DP, Jiang HY. Overexpression of HACE1 in gastric cancer inhibits tumor aggressiveness by impeding cell proliferation and migration.

3. Hibi K, Sakata M, Sakuraba K. Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer.

4. Zhou Z, Zhang HS, Zhang ZG. Loss of HACE1 promotes colorectal cancer cell migration upregulation of YAP1.

5. Anglesio MS, Evdokimova V, Melnyk N. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms’ tumor normal kidney.

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