Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead

Author:

Dai Yuxuan1,Lei Chenyi2,Zhang Zhenhao1,Qi Yan1,Lao Kejing1,Gou Xingchun1

Affiliation:

1. Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Academician Workstation of Chen Zhi-nan Medical University, Xi’an Medical University, Xi’an 710021, China

2. College of Pharmacy, Xi\'an Jiaotong University, Xi\'an 710049, China

Abstract

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline. The obvious pathological features of AD are still amyloid plaques and neurofibrillary tangles. Development of disease-modifying treatments for AD has been challenging, with almost all drugs aborted. The amyloid cascade concept has been questioned due to the failures of various amyloid-targeting prospects. Despite this, targeting amyloid-β (Aβ) active im-munotherapy provided some positive results to support this hypothesis and clinical trials of these candidates are ongoing. In this review, we describe the latest advance in therapeutic strategies based on amyloidogenic processing and evaluate the pros and cons of each treatment strategy. We also highlight the current status of the hottest immunotherapy and discuss the future development direc-tion.

Funder

National Natural Science Foundation of China

Scientific Research Program of Shaanxi Education Committee

Natural Science Basic Research Plan in Shaanxi Province of China

Research Foundation of Xi’an Medical University

Publisher

Bentham Science Publishers Ltd.

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine

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