A Perspective on EGFR and Proteasome-based Targeted Therapy for Cancer

Abstract

Background: Cancer is known to be the most leading cause of death worldwide. It is understood that the sources causing cancer are mainly the activity of endogenous oncogenes, non-viral compounds and the fundamental portion of these oncogenes; the tyrosine kinase activity and proteasome activity as the main biomarkers responsible for cell proliferation. These biomarkers can be used as main targets and are believed to be the ‘prime switches’ for the signal communication activity to regulate cell death and cell cycle. Thus, signal transduction inhibitors (ligand receptor tyrosine kinase inhibitors) and proteosome inhibitors can be used as therapeutic modality to block the action of signaling between the cells as well as protein breakdown in order to induce cell apoptosis. Aim: This article highlights the key points and overview of the recent patents on EGFR and proteosome based inhibitors as a therapeutic efficacy. This review focuses on the patents related to therapeutic agent, process preparation and product patent. Objective: The main objective of this study is to facilitate the advancement and current perspectives in the treatment of cancer. Conclusion: There are numerous strategies that are discussed in these patents to improve the pharmacokinetics and pharmacodynamics of EGFR and proteosome inhibitors. Further, resistance of targeted therapy after long term treatment can be overcome by using various excipients that can be used as a strategy to carry drug in order to overcome resistance. However, there is a need and scope for improving targeted therapeutics for cancer treatment with better fundamentals and characteristics. The widespread research over cancer therapy can create the path for future advancements in therapy with more prominent outcomes.