Affiliation:
1. Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research, Kolkata,
India
Abstract
:
The gut has been colonized with bacteria, fungi, viruses, archaea, eukarya. The human
and bacterial cells are found in a 1:1 ratio, while the variance in the diversity of gut microbiota
may result in dysbiosis. Gut dysbiosis may result in various pathological manifestations. Beneficial
gut microbiota may synthesize short-chain fatty acids like acetate, butyrate, propionate. Gram-negative
organisms are the primary source of LPS, a potent pro-inflammatory mediator. Both gut microbiota
and microbial products may be involved in immunomodulation as well as inflammation. Prebiotics
and probiotics are being explored as therapeutic agents against various inflammatory and autoimmune
disorders. Here, we discuss the molecular mechanisms involved in gut bacteria mediated
modulation of various inflammatory and autoimmune disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine
Cited by
2 articles.
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