Potential Phytochemicals for Prevention of Familial Breast Cancer with BRCA Mutations-Reference-Cited by-同舟云学术

Potential Phytochemicals for Prevention of Familial Breast Cancer with BRCA Mutations

Published:2023-04 Issue:6 Volume:24 Page:521-531
ISSN:1389-4501
Container-title:Current Drug Targets
language:en
Short-container-title:CDT

Author:

Shahiwala Aliasgar Fakruddin¹^ORCID,Khan Gazala Afreen²

Affiliation:

1. Department of Pharmaceutics, Dubai Pharmacy College for Girls, Dubai, United Arab Emirates

2. Department of Clinical Pharmacy & Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai, United Arab Emirates

Abstract

Abstract: Breast cancer has remained a global challenge and the second leading cause of cancer mortality in women and family history. Hereditary factors are some of the major risk factors associated with breast cancer. Out of total breast cancer cases, 5-10% account only for familial breast cancer, and nearly 50% of all hereditary breast cancer are due to BRCA1/BRCA2 germline mutations. BRCA1/2 mutations play an important role not only in determining the clinical prognosis of breast cancer but also in the survival curves. Since this risk factor is known, a significant amount of the healthcare burden can be reduced by taking preventive measures among people with a known history of familial breast cancer. There is increasing evidence that phytochemicals of nutrients and supplements help in the prevention and cure of BRCA-related cancers by different mechanisms such as limiting DNA damage, altering estrogen metabolism, or upregulating expression of the normal BRCA allele, and ultimately enhancing DNA repair. This manuscript reviews different approaches used to identify potential phytochemicals to mitigate the risk of familial breast cancer with BRCA mutations. The findings of this review can be extended for the prevention and cure of any BRCAmutated cancer after proper experimental and clinical validation of the data.

Publisher

Bentham Science Publishers Ltd.

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine

Reference163 articles.

1. Golubnitschaja O.; Debald M.; Yeghiazaryan K.; Kuhn W.; Pešta M.; Costigliola V.; Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumour Biol 2016,37(10),12941-12957

2. Kmietowicz Z.; Genetic screening could improve breast cancer prevention, study finds. BMJ 2015,350(apr09 13),h1879

3. Mavaddat N.; Pharoah P.D.P.; Michailidou K.; Tyrer J.; Brook M.N.; Bolla M.K.; Wang Q.; Dennis J.; Dunning A.M.; Shah M.; Luben R.; Brown J.; Bojesen S.E.; Nordestgaard B.G.; Nielsen S.F.; Flyger H.; Czene K.; Darabi H.; Eriksson M.; Peto J.; dos-Santos-Silva I.; Dudbridge F.; Johnson N.; Schmidt M.K.; Broeks A.; Verhoef S.; Rutgers E.J.; Swerdlow A.; Ashworth A.; Orr N.; Schoemaker M.J.; Figueroa J.; Chanock S.J.; Brinton L.; Lissowska J.; Couch F.J.; Olson J.E.; Vachon C.; Pankratz V.S.; Lambrechts D.; Wildiers H.; Van Ongeval C.; van Limbergen E.; Kristensen V.; Grenaker Alnæs G.; Nord S.; Borresen-Dale A.L.; Nevanlinna H.; Muranen T.A.; Aittomäki K.; Blomqvist C.; Chang-Claude J.; Rudolph A.; Seibold P.; Flesch-Janys D.; Fasching P.A.; Haeberle L.; Ekici A.B.; Beckmann M.W.; Burwinkel B.; Marme F.; Schneeweiss A.; Sohn C.; Trentham-Dietz A.; Newcomb P.; Titus L.; Egan K.M.; Hunter D.J.; Lindstrom S.; Tamimi R.M.; Kraft P.; Rahman N.; Turnbull C.; Renwick A.; Seal S.; Li J.; Liu J.; Humphreys K.; Benitez J.; Pilar Zamora M.; Arias Perez J.I.; Menéndez P.; Jakubowska A.; Lubinski J.; Jaworska-Bieniek K.; Durda K.; Bogdanova N.V.; Antonenkova N.N.; Dörk T.; Anton-Culver H.; Neuhausen S.L.; Ziogas A.; Bernstein L.; Devilee P.; Tollenaar R.A.E.M.; Seynaeve C.; van Asperen C.J.; Cox A.; Cross S.S.; Reed M.W.R.; Khusnutdinova E.; Bermisheva M.; Prokofyeva D.; Takhirova Z.; Meindl A.; Schmutzler R.K.; Sutter C.; Yang R.; Schürmann P.; Bremer M.; Christiansen H.; Park-Simon T.W.; Hillemanns P.; Guénel P.; Truong T.; Menegaux F.; Sanchez M.; Radice P.; Peterlongo P.; Manoukian S.; Pensotti V.; Hopper J.L.; Tsimiklis H.; Apicella C.; Southey M.C.; Brauch H.; Brüning T.; Ko Y.D.; Sigurdson A.J.; Doody M.M.; Hamann U.; Torres D.; Ulmer H.U.; Försti A.; Sawyer E.J.; Tomlinson I.; Kerin M.J.; Miller N.; Andrulis I.L.; Knight J.A.; Glendon G.; Marie Mulligan A.; Chenevix-Trench G.; Balleine R.; Giles G.G.; Milne R.L.; McLean C.; Lindblom A.; Margolin S.; Haiman C.A.; Henderson B.E.; Schumacher F.; Le Marchand L.; Eilber U.; Wang-Gohrke S.; Hooning M.J.; Hollestelle A.; van den Ouweland A.M.W.; Koppert L.B.; Carpenter J.; Clarke C.; Scott R.; Mannermaa A.; Kataja V.; Kosma V.M.; Hartikainen J.M.; Brenner H.; Arndt V.; Stegmaier C.; Karina Dieffenbach A.; Winqvist R.; Pylkäs K.; Jukkola-Vuorinen A.; Grip M.; Offit K.; Vijai J.; Robson M.; Rau-Murthy R.; Dwek M.; Swann R.; Annie Perkins K.; Goldberg M.S.; Labrèche F.; Dumont M.; Eccles D.M.; Tapper W.J.; Rafiq S.; John E.M.; Whittemore A.S.; Slager S.; Yannoukakos D.; Toland A.E.; Yao S.; Zheng W.; Halverson S.L.; González-Neira A.; Pita G.; Rosario Alonso M.; Álvarez N.; Herrero D.; Tessier D.C.; Vincent D.; Bacot F.; Luccarini C.; Baynes C.; Ahmed S.; Maranian M.; Healey C.S.; Simard J.; Hall P.; Easton D.F.; Garcia-Closas M.; Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst 2015,107(5)

4. Genetic Testing for Breast Cancer. Available from:

5. Rennert G.; Bisland-Naggan S.; Barnett-Griness O.; Bar-Joseph N.; Zhang S.; Rennert H.S.; Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med 2009,357(2),115-23

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