Affiliation:
1. Department of Pharmaceutical Analysis and Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur, India
Abstract
Background:
A pharmaceutical will be clinically accepted if it is impurity-free and its
dose is accurately maintained. For this, the contribution of analytical techniques for developing
and validating a new pharmaceutical dosage form cannot be overlooked.
Introduction:
Tolterodine tartrate is a potent competitive muscarinic receptor antagonist. It binds
to the muscarinic M3 receptors in the bladder selectively and competitively. It is used to treat urinary
incontinence and overactive bladder syndrome. The 5-hydroxymethyl derivative is the
pharmacologically active metabolite of Tolterodine tartrate, which is as potent as the main drug.
It is available with α-adrenergic blocker Tamsulosin in combined pharmaceutical formulations,
treating benign prostatic hyperplasia in men. This review article presents several analytical methods,
including HPLC, HPTLC, UV-Visible spectrophotometry, spectrofluorimetry, electroanalytical,
and various hyphenated techniques like GC-MS, LC-MS, LC-MS-MS, etc., for estimation of
Tolterodine tartrate is present as a single material or in combined form in bulk materials, different
pharmaceutical formulations, and biological matrices.
Conclusion:
HPLC and spectrophotometry are the most widely used methods for determining the
drug in the bulk and pharmaceutical dosage form among all these methods. LC-MS and LC-MSMS
are widely used for the estimation of Tolterodine tartrate from plasma and other biological
fluids. All the methods included in this article are accurate, sensitive, and cost-effective.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Molecular Medicine,Biochemistry,Biophysics