Affiliation:
1. Department of Pharmaceutical Analysis and Chemistry, ISF College of Pharmacy, Ghal Kalan, Moga, 142001, Punjab,
142001 India
Abstract
Background:
Hydroxychloroquine (HCQ) was originally launched as an antimalarial
drug, but now it is also used as a slow-acting anti-rheumatic drug. It contains equal proportions
of (-)-(R)-hydroxychloroquine and (+)-(S)-hydroxychloroquine.
Introduction:
Hydroxychloroquine, a synthetic 4-aminoquinoline derivative, possesses antimalarial,
anti-rheumatic activity and also exerts beneficial effects on lupus erythematous disease.
Substantial levels of three metabolites of HCQ, which are desethylchloroquine (DCQ), bisdesethylhydroxychloroquine
(BDCQ), and desethylhydroxychloroquine (DHCQ), have been determined
by various analytical techniques from blood and plasma.
Methods:
Various analytical techniques have been reported for asynchronous and simultaneous
estimation of HCQ and their metabolites in pharmaceuticals and biological samples like (serum,
whole blood, and urine). The analytical techniques are Square-wave voltammetry employed with
the cathodically pretreated boron-doped diamond electrode, fast UHPLC–fluorescent method, UV
spectrophotometry, UHPLC-UV analysis, RP-HPLC, mass spectrometry, NMR, and CE.
Results:
We have complied various analytical methods to detect HCQ with its various metabolites
simultaneously or alone in pharmaceutical dosage forms, biological and environmental
samples.
Conclusion:
The authors believe that the above-mentioned studies compiled in this report will
give a choice to readers to select the most appropriate and suitable method for the analysis of
HCQ. Further, it is also believed that this study will help the researchers to develop a more sensitive,
convenient, and rapid method for these based on literature reports.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Molecular Medicine,Biochemistry,Biophysics
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献