Neuro-inflammatory Responses in Alzheimer’s v/s Parkinson’s Diseases

Abstract

Neurodegenerative diseases are a heterogeneous group of disorders and are the leading cause of morbidity and disability. These are described by the progressive degeneration of the neurons and impaired function of the central nervous system. Prevailing neurodegenerative diseases in the world include Alzheimer's disease and Parkinson's disease and reports predict that on average, the prevalence of both diseases will double in a span of the next twenty years. Pieces of evidence showed that the immune system is profoundly involved in brain development, maintenance, and repair as well as in damage, therefore, may provide a wide scope to focus on the neuroinflammation-based therapeutic approaches. In this chapter, the various neuroinflammatory responses will be discussed during the onset and progression of both Alzheimer’s and Parkinson’s disease pathologies. We will be focusing on both central and peripheral inflammatory responses and their consideration for disease diagnosis and therapeutics.