Application of LFER to the N(1)-H Acidities of Five-Membered Nitrogen Heterocyclic Ring Systems: A Review on Graduate Chemical Education Exercise-Reference-Cited by-同舟云学术

Application of LFER to the N(1)-H Acidities of Five-Membered Nitrogen Heterocyclic Ring Systems: A Review on Graduate Chemical Education Exercise

Published:2022-07 Issue:2 Volume:12 Page:117-127
ISSN:1877-9468
Container-title:Current Physical Chemistry
language:en
Short-container-title:CPC

Author:

Vandanapu Jagannadham¹,Rachuru Sanjeev²

Affiliation:

1. Department of Chemistry, Osmania University, Hyderabad 500007, India

2. Department of Chemistry, Geethanjali College of Engineering and Technology, Cheeryal 501301, Telangana, India

Abstract

Abstract: An attempt is made for the first time in our laboratory to apply the Hammett and Taft equations to the five-membered heterocyclic ring systems pyrroles, pyrazoles, imidazole, and triazoles. It is shown that the pKa values of N(1)-H acidities of 3-X-pyrroles, 3-Xpyrazole, 4-X-pyrazole, 4-X-imidazole, 3-X-1,2,4-triazole and 4-X-1,2,3-triazole correlated well with Hammett σ values.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine

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