Affiliation:
1. Department of Neurology, Affiliated Hospital 2 of Nantong University, Nantong, 226000, Jiangsu Province, China
Abstract
Objective:
White matter hyperintensity (WMH) is related to the increased risk of ischemic
stroke. It is unclear if H-type hypertension (H-type HBP) is associated with periventricular
WMH (PWMH) and deep WMH (DWMH) of acute ischemic stroke. This study investigated the
correlation between H-type HBP and the severity of PWMH and DWMH in acute ischemic stroke.
Methods:
Consecutive patients with acute ischemic stroke were included in this cross-sectional
observational study. The patients were divided into the following groups: the normal group, the
simple hypertension group (Simple HBP), the simple hyperhomocysteinemia group (Simple
HHcy) and the H-type HBP group. MR imaging and relevant clinical variables were obtained from
the medical records. PWMH and DWMH were rated by using the Fazekas scale (score 0-3). All
patients were defined to have moderate-severe PWMH or DWMH (score 2-3) and no or mild
group (score 0-1). Multivariate binary logistic regression analysis was performed to determine the
relationship between H-type HBP and the severity of PWMH and DWMH.
Results:
Among 542 patients, 227 had moderate-severe PWMH and 228 had moderate-severe
DWMH. Compared to the no or mild group, patients with moderate-severe PWMH (median age:
73 vs. 63 years) and DWMH (median age: 70 vs. 65.5 years) were older. Compared to the no or
mild group, moderate-severe PWMH and DWMH were associated with a history of ischemic
stroke (moderate-severe PWMH vs. no or mild group 20.7% vs. 11.7%, p = 0.004;moderatesevere
DWMH vs. no or mild group 20.2% vs. 12.1%, p = 0.010); We found that H-type HBP was
an independent risk factor for PWMH (OR 2.64, 95% CI 1.34-5.21) and DWMH (OR 3.64, 95%
CI 1.82-7.26) after adjusting for the effect of relevant risk factors.
Conclusion:
This study suggests that H-type HBP is associated with the severity of PWMH and
DWMH in acute ischemic stroke patients, which deserves further prevention measures.
Funder
Nantong Municipal Health Commission, China
Publisher
Bentham Science Publishers Ltd.
Subject
Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology,Neurology (clinical)