Affiliation:
1. Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang,
China
Abstract
Objective:
Cognitive impairment has been suggested to be associated with coronary artery
disease [CAD]; however, the underlying mechanism is not fully understood. Our current study
aimed to explore the brain activity in CAD patients compared to healthy controls [HCs].
Methods:
Twenty-two CAD patients and 23 HCs were enrolled in our study. A low-frequency oscillation
at the voxel level in all participants based on the amplitude of low-frequency fluctuations
[ALFF] was measured using resting-state functional magnetic resonance imaging. All participants
underwent neuropsychological examinations [Mini-Mental State Examination, MMSE and Montreal
Cognitive Assessment, MoCA] and visual acuity examination.
Results:
CAD patients showed significantly lower ALFF values [P < 0.05] in the right precuneus
gyrus [Precuneus_R], left supramarginal gyrus [Supramarginal_L], left angular gyrus [Angular_L],
and left middle cingulum gyrus [Cingulum_Mid_L] than healthy controls. Lower MoCA scores in
CAD patients significantly correlated with lower Supramarginal_L [P = 0.001] and Cingulate_
Mid_L [P = 0.004] ALFF values. Reduced visual acuity significantly correlated with lower
Precuneus_R [P = 0.019] and Cingulate_Mid_L [P = 0.011] ALFF values in CAD patients.
Conclusion:
These findings may provide further insight into the underlying neuropathophysiology
of CAD with cognitive impairment.
Funder
Zhejiang Provincial Medical and Health Science and Technology Project
Publisher
Bentham Science Publishers Ltd.
Subject
Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology
Cited by
3 articles.
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