Author:
Conjeevaram Arvind,Lohia Priyangani,GS Ravishankar,Vankalakunti Mahesha
Abstract
It is well known that patients with mechanical heart valves may develop sheer stress related hemolysis and consequent pigment related nephropathy. Warfarin Related Nephropathy (WRN) is a relatively new entity and defined as Acute Kidney Injury (AKI) in the setting of an INR of > 3.0 excluding other obvious etiologies. A biopsy diagnosis of WRN is conducted when red blood cell casts are noted filling and blocking the tubules; additionally, glomerular hemorrhage may be observed. We describe a patient with mechanical heart valves on oral anticoagulation who developed both pigment nephropathy and WRN causing AKI.
Publisher
Bentham Science Publishers Ltd.
Reference8 articles.
1. Brodsky SV, Satoskar A, Chen J, et al. Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: a report of 9 cases. Am J Kidney Dis 2009; 54 (6) : 1121-6.
2. Leonardi P, Ruol A. Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. Blood 1960; 16 : 1029-38.
3. Concepcion B, Korbet SM, Schwartz MM. Intravascular hemolysis and acute renal failure after mitral and aortic valve repair. Am J Kidney Dis 2008; 52 (5) : 1010-5.
4. Skoularigis J, Essop MR, Skudicky D, Middlemost SJ, Sareli P. Frequency and severity of intravascular hemolysis after left-sided cardiac valve replacement with Medtronic Hall and St. Jude Medical prostheses, and influence of prosthetic type, position, size and number. Am J Cardiol 1993; 71 (7) : 587-91.
5. Heyman SN, Rosen S, Fuchs S, Epstein FH, Brezis M. Myoglobinuric acute renal failure in the rat: A role for medullary hypoperfusion, hypoxia, and tubular obstruction. J Am Soc Nephrol 1996; 7 (7) : 1066-74.
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