Affiliation:
1. Centre for Translational & Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi
110062, India
Abstract
Background and Objective:
Interferon-alpha (IFN-α) is an important treatment modality for the hepatitis
C virus (HCV). However, treatment with IFN-α is often associated with cognitive difficulties in
HCV patients. Thus, this systematic review was performed to assess the effects of IFN-α on cognitive
functioning in patients suffering from HCV.
Methods:
Relevant literature was identified by performing a comprehensive literature search in
major databases including PubMed, clinicaltrials.gov, and Cochrane Central using a combination
of suitable keywords. We retrieved studies that were published from the start of each database until
August 2021.
Results:
Out of 210 articles, 73 studies were selected after removing the duplicates. In the first
pass, 60 articles were excluded. Out of 13 full-text articles, only 5 articles qualified for qualitative
analyses in the second pass. We observed conflicting results concerned with the use of IFN-α and
the risk of neurocognitive impairment in HCV patients.
Conclusion:
In conclusion, we have observed conflicting results regarding the impact of INF-α
treatment on the cognitive functioning of patients suffering from HCV. Thus, there is an urgent
need for an extensive study to evaluate the exact association between INF-αtherapy and cognitive
functioning in HCV patients.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Pharmacology,Toxicology
Cited by
1 articles.
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