Affiliation:
1. Department of Medicine (ID Division), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
2. Department of Psychiatry, All India Institute of Medical Sciences, Rishikesh, India
Abstract
Introduction:
Adverse drug reactions (ADR) are defined as any harmful or unpleasant
events or injuries resulting from the use of any particular drug. Among those antibiotics that cause
adverse reactions, amoxicillin is one of them. Catatonia and vasculitic rash are its rare adverse
effects.
Case Presentation:
A 23-year-old postpartum female, with a history of taking empirical Amoxiclav
(amoxicillin-clavulanic acid 625 mg) injection and oral tablets for episiotomy wound, presented
with altered sensorium and fever followed by maculopapular rash. On examination, she had
generalized rigidity with waxy flexibility that improved by lorazepam challenge and was diagnosed
as catatonia. On evaluation, amoxicillin was found to be precipitating catatonia in this patient.
Conclusion:
Since the diagnosis of catatonia is often missed, any cases with clinical presentation
of fever, rash, altered sensorium, and generalized rigidity should also be suspected for druginduced
ADR and the precipitating factor should be searched for.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Pharmacology,Toxicology
Reference10 articles.
1. Coleman J.J.; Pontefract S.K.; Adverse drug reactions. Clin Med 2016,16(5),481-485
2. Daniels J.; Catatonia: Clinical aspects and neurobiological correlates. J Neuropsychiatry Clin Neurosci 2009,21(4),371-380
3. Edinoff A.N.; Kaufman S.E.; Hollier J.W.; Catatonia: Clinical overview of the diagnosis, treatment, and clinical challenges. Neurol Int 2021,13(4),570-586
4. McKeown N.J.; Bryan J.H.; Horowitz B.Z.; Catatonia associated with initiating paliperidone treatment. West J Emerg Med 2010,11(2),186-188
5. Essali N.; Miller B.J.; Psychosis as an adverse effect of antibiotics. Brain Behav Immun Health 2020,9,100148