Exposure to Endocrine-disrupting Chemicals and Environmental Toxins Attributing to Polycystic Ovarian Syndrome

Abstract

Abstract: Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by ex-cess androgen and infertility due to anovulatory failure. A significant fraction of the world's popu-lation is affected by the infertility condition known as PCOS. Due to the disease's complicated na-ture and overlapping symptoms, diagnosis of the condition is frequently challenging. Exogenous compounds or combinations known as endocrine-disrupting chemicals (EDCs) can imitate the ef-fects of steroid hormones and obstruct their metabolism. EDCs and this condition have recently been the subject of intensive research to better understand the possible contribution of these sub-stances to the pathophysiology of PCOS. It was shown that EDC exposure can be connected to PCOS in either a direct or indirect way since PCOS is linked to higher levels of oxidative stress and inflammation, which lead to obesity, insulin resistance, and infertility. This review's objective is to investigate how exposure to environmental contaminants affects the etiology of polycystic ovarian syndrome.