Comparison of the Effect of Jalinus Syrup and Ondansetron Syrup on Nausea and Vomiting during Pregnancy in Pregnant Women: Randomized Clinical Trial

Abstract

Objective: This study aimed to compare the effect of jainus syrup and Ondansetron syrup on nausea and vomiting during pregnancy. Methodology: The present study is a single-blind randomized clinical trial that was conducted on 120 pregnant women referred to the health centers of Hamadan during 2017-2018. The participants were randomly divided into two groups, control and intervention, with 60 subjects in each group. Two groups of 60 received jalinus syrup and Ondansetron syrup for 7 days. Data collection tools, demographic questionnaire, and information associated with pregnancy, and PUQE-24 questionnaire were used to assess the severity of nausea and vomiting, and questions related to the assessment of side effects as well asparticipants’ level of satisfaction with the treatment were provided. All the data were analyzed using the SPSS software version 16. P-value < 0.05 was considered significant. Results: The severity of nausea and vomiting in both groups decreased after the intervention, but considering the independent t-test, there was no significant difference between the two groups in terms of severity of nausea (P >0.05). According to the Chi-square test, the severity of nausea of all participants was moderate in both groups before taking the medication, and after taking the medication, the severity of nausea reduced in most participants and they were placed in the mild group. Conclusions: Due to the similar effects of jalinus syrup and Ondansetron syrup in the treatment of nausea and vomiting in pregnancy and the absence of side effects arising from its use, herbal medicine can be used instead of chemical drugs. Clinical Trials registered Code: IRCT201709079014N184