Comparison of midwifery consultation and fluoxetine on IVF outcomes in depressed infertile woman: a clinical trial research study

Abstract

Background: A lot of research has been done to improve the treatment of infertility and increase the quality and effectiveness of performance. Objective: In this randomized clinical trial study (IRCT2014031116911N2), we compared the effect of Fluoxetine and midwifery consultation on infertile women suffering from depression and the focus of the study is on the results of, InVitro Fertilization (IVF) treatment. Methods: 90 infertile women who suffered from mild to moderate depression according to Beck Inventory and had undergone IVF treatment were selected and randomly divided into 3 groups. The control group, the second group were treated with Fluoxetine 20 mg, and the third group received 6 sessions of midwifery consultation and then the outcomes were reviewed. The amount of cortisol in the women’s sera was measured in three stages and the level of depression and anxiety was measured in two stages. Results: Pregnancy rate in the midwifery consultation group (n=13) was about two times as high as that in the fluoxetine group (n=7) and three times as high as that in the control group (n=4); there was a statistically significant difference among the groups (P=0.016). As to the abortions occurring in each group (P>0.05). Conclusion: Providing the people undergoing IVF treatment with emotional and mental support will increase their chances of pregnancy and this kind of support will be helpful for the patients if it is given in the form of midwifery consultation.