Affiliation:
1. Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Abstract
Background:
Ultrasound-guided sclerosis has been used to treat ovarian endometriotic
cysts since 1988. However, compared with cystectomy, sclerotherapy's effectiveness and safety are
questionable.
Objective:
To compare ultrasound-guided sclerotherapy and ovarian cystectomy in the treatment of
ovarian endometriosis through a systematic review and meta-analysis.
Methods:
PubMed-MEDLINE, EMBASE, Cochrane, and Scopus databases were searched, and related literature was collected. The two treatments' recurrence rate, pain relief rate, pregnancy rate, technical success rate, and complication rate were directly compared.
Results:
Six studies (386 patients) were included. The risk of recurrence with sclerotherapy was higher
than that with cystectomy (OR 1.57, p = 0.52). Subgroup analysis showed that an indwelling time >
10 min was not significantly different regarding recurrence risk between sclerotherapy and cystectomy
(OR 1.01, p = 0.99). When the indwelling time was ≤ 10 min, the risk of recurrence with sclerotherapy
was significantly higher than that with cystectomy (OR 22.01, p = 0.001). The pregnancy rate after
cystectomy was lower than that after sclerosis (OR 1.67, p = 0.22). Complications in the study were
graded according to the Clavien‒Dindo classification and statistical analysis showed that the probability
of serious complications (Grade III-V) with cystectomy was higher than that with sclerosis
(16.67% vs. 0%).
Conclusion:
Ultrasound-guided sclerotherapy was not inferior to cystectomy in terms of recurrence
rate or pregnancy rate, and the incidence of severe complications was lower than that in the cystectomy group. Sclerotherapy is a safe and effective alternative treatment for ovarian endometriosis.
Funder
Joint Fund of the Bureau of Science and Technology of Chongqing and the Health Committee of Chongqing
Publisher
Bentham Science Publishers Ltd.
Subject
Obstetrics and Gynecology