Dimerization of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity

Author:

Lorenzon Esteban N.1,Piccoli Julia P.2,Santos-Filho Norival A.3,Cilli Eduardo M.2

Affiliation:

1. Unidade Academica Especial da Saude, Universidade Federal de Jatai, Jatai-GO, Brazil

2. Instituto de Quimica, UNESP- Universidade Estadual Paulista, Araraquara-SP, Brazil

3. UNESP- Universidade Estadual Paulista, Campus Experimental de Registro, Registro, Sao Paulo, Brazil

Abstract

Antimicrobial resistance is a global health problem with strong social and economic impacts. The development of new antimicrobial agents is considered an urgent challenge. In this regard, Antimicrobial Peptides (AMPs) appear to be novel candidates to overcome this problem. The mechanism of action of AMPs involves intracellular targets and membrane disruption. Although the exact mechanism of action of AMPs remains controversial, most AMPs act through membrane disruption of the target cell. Several strategies have been used to improve AMP activity, such as peptide dimerization. In this review, we focus on AMP dimerization, showing many examples of dimerized peptides and their effects on biological activity. Although more studies are necessary to elucidate the relationship between peptide properties and the dimerization effect on antimicrobial activity, dimerization constitutes a promising strategy to improve the effectiveness of AMPs.

Funder

Fundação Amparo a Pesquisa do Estado de São Paulo

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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