The Molecular Mechanism of CoenzymeQ10 on Pyroptosis and its Related Diseases: A Review-Reference-Cited by-同舟云学术

The Molecular Mechanism of CoenzymeQ10 on Pyroptosis and its Related Diseases: A Review

Published:2022-11 Issue:11 Volume:29 Page:911-916
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Li Xian-Hui¹,Xiang Qiong²,Fu Chuan-Jun²

Affiliation:

1. Institute of Pharmaceutical Sciences, Jishou University, Hunan, China

2. Institute of Medicine, Medical Research Center, Jishou University, Hunan, China

Abstract

Background: In recent years, cell pyroptosis has made it widely concerned. Pyroptosis is characterized by the activation of pathways leading to the activation of NLRP3 inflammasome and its downstream effector, such as interleukin (IL)-1β and IL-18, which has close relationship with inflammation. Recent evidence supports that CoenzymeQ10 (CoQ10) reduces related inflammatory factors (NLRP3、IL-1β and IL-18), which are associated with cell pyroptosis. This paper reviews the possible mechanisms of CoQ10 inhibiting pyroptosis of different cells and its possible mechanism. Further research is needed to better define the response effects of CoQ10 on specific aspects of cell pyroptosis (such as priming, promotion, and signaling), and to further investigate the organizational and cellular mechanisms by which CoQ10 reduces pyroptosis in different cells.

Funder

National natural Science Foundation of China

National natural Science Foundation Hunan Province

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

Reference63 articles.

1. Broz P.; Pelegrín P.; Shao F.; The gasdermins, a protein family executing cell death and inflammation. Nat Rev Immunol 2020,20(3),143-157

2. Wang T.; Yang Y.; Sun T.; Qiu H.; Wang J.; Ding C.; Lan R.; He Q.; Wang W.; The pyroptosis related long noncoding RNA signature predicts prognosis and indicates immunotherapeutic efficiency in hepatocellular carcinoma. Front Cell Dev Biol 2022,10,779269

3. Miao E.A.; Rajan J.V.; Aderem A.; Caspase-1-induced pyroptotic cell death. Immunol Rev 2011,243(1),206-214

4. Li Y.; Huang H.; Liu B.; Zhang Y.; Pan X.; Yu X.Y.; Shen Z.; Song Y.H.; Inflammasomes as therapeutic targets in human diseases. Signal Transduct Target Ther 2021,6(1),247

5. Dludla P.V.; Orlando P.; Silvestri S.; Marcheggiani F.; Cirilli I.; Nyambuya T.M.; Mxinwa V.; Mokgalaboni K.; Nkambule B.B.; Johnson R.; Mazibuko M.S.E.; Muller C.J.F.; Louw J.; Tiano L.; Coenzyme Q10 supplementation improves adipokine levels and alleviates inflammation and lipid peroxidation in conditions of metabolic syndrome: A meta-analysis of randomized controlled trials. Int J Mol Sci 2020,21(9),3247