Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors-Reference-Cited by-同舟云学术

Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors

Published:2022-07 Issue:7 Volume:29 Page:574-583
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Jin Shujuan¹,Zhang Mengjiao²

Affiliation:

1. Peking University Shenzhen Graduate School, Shenzhen, 518055, China

2. Hunan University of Chinese Medicine, Changsha, 410208, China

Abstract

Abstract: The coronavirus family consists of pathogens that seriously affect human and animal health. They mostly cause respiratory or enteric diseases, which can be severe and life-threatening, such as coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome (SARS), and Middle East Respiratory Syndrome (MERS) in humans. The conserved coronaviral papain-like protease is an attractive antiviral drug target because it is essential for coronaviral replication, and it also inhibits host innate immune responses. This review focuses on the latest research progress relating to the mechanism of coronavirus infection, the structural and functional characteristics of coronavirus papain-like protease, and the potent inhibitors of the protease.

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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