The Emerging Roles of circRNAs in Papillary Thyroid Carcinoma: Molecular Mechanisms and Biomarker Potential-Reference-Cited by-同舟云学术

The Emerging Roles of circRNAs in Papillary Thyroid Carcinoma: Molecular Mechanisms and Biomarker Potential

Published:2023-09 Issue:9 Volume:30 Page:709-718
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Ye Haihan¹,Sun Xiaoyang²,Ding Qianyun³,Yang Enyu¹,Zhao Shuo¹,Fan Xiaowei¹,Fang Meiyu⁴,Ding Xianfeng¹

Affiliation:

1. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310023, P.R. China

2. Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, M5S2E8, Canada

3. Department of 'A', The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, 310023, P.R. China

4. Department of Rare and Head and Neck Oncology, Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, 310005, P.R. China

Abstract

Abstract: Papillary thyroid carcinoma (PTC) is a common endocrine malignant tumor. The incidence of PTC has increased in the past decades and presents a younger trend. Accumulating evidence indicates that circular RNAs (circRNAs), featured with non-linear, closed-loop structures, play pivotal roles in tumorigenesis and regulate cell biological processes, such as proliferation, migration, and invasion, by acting as microRNA (miRNA) sponges. Additionally, due to their unique stability, circRNAs hold promising potential as diagnostic biomarkers and effective therapeutic targets for PTC treatment. In this review, we systematically arrange the expression level of circRNAs, related clinical characteristics, circRNA-miRNA-mRNA regulatory network, and molecular mechanisms. Furthermore, related signaling pathways and their potential ability of diagnostic biomarkers and therapeutic targets are discussed, which might provide a new strategy for PTC diagnosis, monitoring, and prognosis.

Funder

Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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