A Review of the Physiological Role of Hypocretin in the Ventral Tegmental Area in Reward and Drug Dependence-Reference-Cited by-同舟云学术

A Review of the Physiological Role of Hypocretin in the Ventral Tegmental Area in Reward and Drug Dependence

Published:2023-09-06 Issue:8 Volume:30 Page:619-625
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Kourosh-Arami Masoumeh¹,Komaki Alireza²,Gholami Masoumeh³

Affiliation:

1. Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

2. Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

3. Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran

Abstract

Abstract: Orexin (OX, hypocretin: HCRT) as a neuropeptide is produced in a distinct population of neurons in the posterior lateral hypothalamus (LH). OX neurons implicate in reward function. OX makes a main input from the hypothalamus to the ventral tegmental area (VTA) of the midbrain. OX, through OX receptors (OXR1, OXR2) activates VTA dopamine (DA) neurons. VTA neurons are involved in reward processing and motivation. In this review, we will discuss the OX effect on addiction through VTA activation and related areas of the brain.

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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