Affiliation:
1. Howard Hughes Medical Institute and Department of Biology, Indiana University, Bloomington, IN 47405, United States
Abstract
The Baculovirus Expression Vector System (BEVS) is a workhorse for recombinant
protein expression for over thirty-five years. Ever since it was first used to overexpress the human
IFN-β protein, the system has been engineered and modified several times for quick and easy
expression and scale-up of the recombinant proteins. Multiple gene assemblies performed on the
baculovirus genome using synthetic biology methods lead to optimized overexpression of the multiprotein
complexes. Nowadays, several commercially available BEVS platforms offer a variety of
customizable features, and often it is confusing which one to choose for a novice user. This short
review is intended to be a one-stop guide to the commercially available baculovirus technology for
heterologous protein expression in the insect cells, which users can refer to choose from popular
and desirable BEVS products or services.
Publisher
Bentham Science Publishers Ltd.
Subject
Biochemistry,General Medicine,Structural Biology
Cited by
10 articles.
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