Affiliation:
1. Departamento de Morfologia - Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Abstract
Huntington’s Disease (HD) is an autosomal dominant, progressive neurodegenerative
disorder characterized by severe symptoms, including motor impairment, cognitive decline, and
psychiatric alterations. Several systems, molecules, and mediators have been associated with the
pathophysiology of HD. Among these, there is the Renin-Angiotensin System (RAS), a peptide
hormone system that has been associated with the pathology of neuropsychiatric and
neurodegenerative disorders. Important alterations in this system have been demonstrated in HD.
However, the role of RAS components in HD is still unclear and needs further investigation.
Nonetheless, modulation of the RAS components may represent a potential therapeutic strategy for
the treatment of HD.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
Fundação de Amparo à Pesquisa de Minas Gerais, Brazil
Publisher
Bentham Science Publishers Ltd.
Subject
Biochemistry,General Medicine,Structural Biology
Cited by
6 articles.
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