Renin-Angiotensin-Aldosterone System and Migraine: A Systematic Review of Human Studies-Reference-Cited by-同舟云学术

Renin-Angiotensin-Aldosterone System and Migraine: A Systematic Review of Human Studies

Published:2020-06-09 Issue:6 Volume:27 Page:512-519
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Sassi Karina Lúcia Moreira¹^ORCID,Martins Laís Bhering¹^ORCID,de Miranda Aline Silva²^ORCID,Teixeira Antonio Lucio¹^ORCID

Affiliation:

1. Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States

2. Department of Morphology, Institute of Biological Sciences, The Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil

Abstract

Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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