Distribution of Voltage-gated Sodium Channel Mutations in Aedes Aegypti Populations from Rural Areas of Indonesia-Reference-Cited by-同舟云学术

Distribution of Voltage-gated Sodium Channel Mutations in Aedes Aegypti Populations from Rural Areas of Indonesia

Published:2023-10-06 Issue:1 Volume:16 Page:
ISSN:1874-9445
Container-title:The Open Public Health Journal
language:en
Short-container-title:TOPHJ

Author:

Cahyati Widya Hary,Siyam Nur,Nugroho Efa

Abstract

Introduction: Semarang has been one of the endemic districts; since 2017, it has contributed to high dengue cases in Central Java. The study was conducted to see the mutation in the Voltage-Gated Sodium Channel (VGSC) Aedes aegypti genera. Materials and Methods: Aedes aegypti from 6 sub-districts in Semarang were examined, where each sub-district was taken from 2-3 villages endemic areas with high fogging intensity in Semarang. Ten larvae samples were taken from each village. Results and Discussion: The results showed that the resistant samples were 48.4% heterozygous and 51.6% homozygous resistant from Bawen, 100% heterozygous resistant from Bandungan, 73.3% heterozygous and 26.7% homozygous resistant from West Ungaran, 65% heterozygous and 35% homozygous resistant from Sumowono, 23.3% heterozygous and 66.7% homozygous resistant, and 10% still susceptible from Ambarawa, and 30% heterozygous and 70% homozygous resistant from East Ungaran districts. Conclusion: Based on the results of the molecular test, the Ae. Aegypti in Semarang Regency has proven resistance to the pyrethroid insecticide cypermethrin.

Publisher

Bentham Science Publishers Ltd.

Link

https://openpublichealthjournal.com/contents/volumes/V16/e187494452309121/e187494452309121.pdf

Reference25 articles.

1. Kemenkes RI. Indonesian Health Profile. Jakarta: Profil Kesehatan Indonesia 2017.

2. WHO. Dengue and Severe Dengue. Geneva: World Health Organization 2014.

3. Cahyati WH, Anggraini TS. Development of Aedes aegypti in water with a variety pH and salinity. Perkembangan Aedes aegypti pada Berbagai Kondisi Ph Air dan Salinitas Air. Higeia 2017; 1 (3) : 1-10.

4. Mulyani A, Boewono DT, Baskoro TA. Study of Aedes aegypti susceptibility against cypermetrin at elementary schools yogyakarta. TMJ 2017; 4 (1) : 25-33.

5. Jahan N, Shahid A. Evaluation of resistance against deltamethrin and cypermethrin in dengue vector from Lahore, Pakistan. J Anim Plant Sci 2013; 23 (5) : 1321-6.