The Application of Nanotechnological Therapeutic Platforms against Gynecological Cancers

Author:

Keyvani Vahideh123,Mollazadeh Samaneh4,Riahi Espanta56,Mahmoudian Reihaneh Alsadat789,Tabari Masoomeh2,Lagzian Elmira7,Ghorbani Elnaz7,Akbarzade Hamed7,Gholami Amir-Sadra7,Gataa Ibrahim Saeed10,Hassanian Seyed Mahdi3,Ferns Gordon A.11,Khazaei Majid7,Avan Amir1213,Anvari Kazem9

Affiliation:

1. Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran

5. Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran

6. Department of Biology, Islamic Azad University, Mashhad Branch, Mashhad, Iran

7. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

8. Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

9. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

10. College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq

11. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex BN1 9PH, UK

12. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;

13. School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane 4059, Australia

Abstract

Abstract: Gynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved bioavailability of various cargos. This review summarizes the application of different nanoplatforms, such as lipid-based, metal-based, and polymeric nanoparticles, to improve the chemo/radio treatments of GC. In the following work, the use of nanoformulated agents to fight GCs has been mentioned in various clinical trials. Although nanosystems have their own challenges, the knowledge highlighted in this article could provide deep insight into translations of NPs approaches to overcome GCs.

Publisher

Bentham Science Publishers Ltd.

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