Bioactive Peptides: Potential Impact on the Treatment of Gastrointestinal Cancers

Author:

Pourali Ghazaleh1,Kazemi Danial2,Pourali Roozbeh3,Rahmani Nafise1,Razzaghi Erfan2,Maftooh Mina1,Fiuji Hamid145,Ghorbani Elnaz4,Khazaei Majid16,Ferns Gordon A.7,Hassanian Seyed Mahdi14,Avan Amir145

Affiliation:

1. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. School of Medicine, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, Iran

3. Student Research Committee, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

4. Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

5. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

6. Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

7. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex BN1 9PH, UK

Abstract

Abstract: We have reviewed the potential use of bioactive peptides in the treatment of gastrointestinal (GI) malignancies, which are a significant cause of morbidity and mortality globally. Conventional therapies, such as surgery, chemotherapy, and radiotherapy, are associated with numerous side effects that may lead to longterm complications. Bioactive peptides are short-chain amino acids that can be extracted from natural sources or synthesized, and they have various potential health benefits, including anti-inflammatory, anti-hypertensive, antioxidant, antimicrobial, and anti-cancer properties. Bioactive peptides can be acquired from animal or plant sources, and can be classified based on their function, such as ACE-inhibiting, antimicrobial, and electrolyte- regulating peptides. Recent studies have demonstrated the promising role of bioactive peptides in tumor suppression, especially when combined with conventional therapies. In this study, we have reviewed the beneficial properties of bioactive peptides and their role in suppressing tumor activity. The mechanisms of bioactive peptides in tumor suppression are discussed. We have further reviewed the findings of preclinical and clinical studies that have investigated the application of bioactive peptides in the treatment of GI cancers. This review highlights the potential use of bioactive peptides as a promising treatment method for GI malignancies to increase the quality of life of GI cancer patients.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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