Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica as Competent Natural Molecules to Treat COVID-19 Virus Variant

Author:

Asif Mohammad1ORCID,Yusuf Mohd2ORCID,Almehmadi Mazen3ORCID,Alsaiari Ahad Amer3,Allahyani Mamdouh3,Aljuaid Abdulelah3,Alsharif Abdulaziz3

Affiliation:

1. Department of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, Lucknow, 226003, Uttar Pradesh, India

2. Department of Natural and Applied Sciences, School of Science and Technology, The Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, 247121 India

3. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia

Abstract

Abstract: Adhatoda vasica (L.) (Acanthaceae) has essential therapeutic roles and is widely used in the indigenous medicine system or Ayurvedic system of medicine. The important goals of the present study are to report the in-silico anti-corona (COVID-19) activity of different phytochemicals present in A. vasica. This study will help to find specific bioactive compounds, and their use as anti- COVID-19 action for human welfare. A. vasica has chemical phytoconstituents with diverse pharmacological activities. These phytoconstituents have been found active against many diseases such as antibacterial, antitubercular, antivirus, antitussive, hepatoprotective, antiinflammatory, antiulcer, antiurolithiatic, abortifacient, radio modulator, cardio-protection, antidiabetic, antioxidant, anticancer, thrombolytic, antimutagenic, etc. Researchers have been lured to the use of natural and sustainable products with substantial therapeutic potential in the current climate of environmental preservation and safe use. These materials permit biological activity, safety, and compatibility with the environment. Using the SARS-CoV-2 spike receptor (6M0J), we evaluated Adhatoda vasica biomolecules for the Covid-19 variant (RBD- COV-2-S). This study is very encouraging and indicates that herbs should be studied more extensively for their therapeutic benefits.

Funder

Research & Innovation, Ministry of Education in Saudi Arabia

Publisher

Bentham Science Publishers Ltd.

Reference44 articles.

1. Kumar A.; Ram J.; Samarth R.M.; Kumar M.; Phytomedicine 2005,12(4),285-293

2. Joshi B.S.; Bai Y.; Puar M.S.; Dubose K.K.; Pelletier S.W.; J Nat Prod 1994,57(7),953-962

3. Claeson U.P.; Malmfors T.; Wikman G.; Bruhn J.G.; J Ethnopharmacol 2000,72(1-2),1-20

4. Prajapati N.D.; Purohit S.S.; Sharma D.D.; Tarun K.; A Handbook of Medicinal Pants 2003,13-14

5. Iyengae M.A.; Jambaiah K.M.; Rao G.O.; Indian Drugs 1994,31,183-186

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Chromatographic Separation of Antihistamine Drugs using HPLC;Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry;2024-04-25

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3