Affiliation:
1. Department of Chemistry, Kırklareli University, Kırklareli, Turkey
2. Department of Biology, Recep Tayyip Erdogan
University, Rize, Turkey
Abstract
Abstract:
In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized.
7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds
norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis
confirmed the structures of all synthesized compounds. The antimicrobial activities of all compounds
were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.
Publisher
Bentham Science Publishers Ltd.