A Convenient Synthesis of Bis-(dihydro)caffeoylspermidines-Reference-Cited by-同舟云学术

A Convenient Synthesis of Bis-(dihydro)caffeoylspermidines

Published:2024-04 Issue:4 Volume:21 Page:386-390
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

He Lili¹,Sun Jian²,Zhou Pengjuan²,Ji Jingwen²,Zhai Lijuan²,Tang Dong²,Ji Jinbo²,Yang Haikang²,Iqbal Zafar²,Yang Zhixiang²

Affiliation:

1. Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan, Ningxia, 750002, P.R. China

2. Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan, Ningxia, 750002, P.R. China

Abstract

Abstract: Caffeoyl spermidines are valuable alkaloids naturally existing in many plant species. These alkaloids are characterized as pharmacologically important ingredients of many plant extracts used in traditional medicines. Bis-caffeoylspermidine and bis-dihydrocaffeoylspermidine exhibit antioxidant, anti-inflammatory, and enzyme inhibition properties that make them valuable natural sources of safer therapeutic agents. However, the limited availability of these compounds in nature derives the attention of synthetic chemists. Therefore, we synthesized bis-caffeoylspermidine and bisdihydrocaffeoylspermidine using cheaper and commercially available starting materials in 97% and 86% overall yields, respectively. The synthetic scheme can be upgraded to the commercial-scale synthesis of these compounds

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry