Facile Synthesis and Antitumor Activity of <i>o</i>-Iodoaromatic Ether-Reference-Cited by-同舟云学术

Facile Synthesis and Antitumor Activity of o-Iodoaromatic Ether

Published:2024-09 Issue:9 Volume:21 Page:784-789
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Mao Xiaoxia¹,Zhang Yuying¹,Wang Keyang²,Zhao Guiqin¹,Zhou Dejun¹^ORCID,Cui Zhengguo³

Affiliation:

1. The laboratory of Chinese Medicine Research and Development in HeBei Province, Institute of Chinese Medicine in Chengde Medical University, Chengde, 067000, China

2. Shandong Daguan Pharmaceutical Technology Co Ltd, Jinan, Shandong, 250100, China

3. Department of Environmental Health, University of Fukui School of Medical Sciences, 23-3 Matsuoka Shimoaizuki Eiheiji, Fukui 910-1193, Japan

Abstract

Abstract: In this study, an efficient method for the synthesis of one type of aromatic ether was introduced, and its antitumor activity was investigated. Specifically, (diacetoxyiodo)arene was prepared from 2-methyliodobenzene and used to oxidize the 4-nitrophenol to give the aromatic ether. Our study further found that aromatic ether has a strong apoptotic effect on U937 monocytes, suggesting that it might be developed as a new drug for the treatment of acute myeloid leukemia.

Funder

Research Foundation for Advanced Talents of Chengde Medical University

Natural Science Foundation of Hebei Province

Postdoctoral Fund of Shandong Daguan Pharmaceutical Technology Co., LTD

Publisher

Bentham Science Publishers Ltd.

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