Affiliation:
1. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University,
Chengdu 610106, China
Abstract
Abstract:
Karanjin (1) is a natural furanoflavonol derivative isolated from seeds of Pongamia pinnata
(L.) Pierre. In this paper, we have accomplished a concise total synthesis of karanjin (1) as well as its
natural analogues pongapinnol D (2), 3-hydroxy-6-methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-
4-one (3) and 3,6-dimethoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one (4). One-pot aerobic oxidation
was the key step to afford the flavonol framework under mild conditions. The anti-inflammatory
properties of synthesized 1–4 were determined against NO production in the LPS-stimulated
RAW264.7 cells.
Funder
National Natural Science Foundation of China
Open Research Fund of the Key Laboratory of Coarse Cereal Processing of the Ministry of Agriculture and Rural Affairs
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry