A New Method for the Synthesis of N, N-Diethyl-m-Methylbenzamide from m-Toluic Acid and Diethylamine Using 1,1'-Carbonyl-di-(1,2,4-triazole) (CDT) as Coupling Agent
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Published:2021-11-19
Issue:
Volume:18
Page:
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Pham Duc Thinh1ORCID,
Nguyen Van Thu1ORCID,
Vu Binh Duong1ORCID,
Phan Dinh Chau2ORCID
Affiliation:
1. Vietnam Military Medical University, Ha Dong district, Hanoi 12108, Vietnam
2. School of Chemical Engineering, Hanoi University of Science and Technology, Haibatrung District, Hanoi 11600, Vietnam
Abstract
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A new, simple method for the synthesis of N, N-dietyl-m-methylbenzamide (DEET) from m-toluic acid and diethylamine using 1,1'-carbonyl-di-(1,2,4-triazole) (CDT) as a coupling agent has been performed. The basic principles of activated carbonyls have been explored with the ability to prepare new amides easily. All reaction by-products are water-soluble as well as removed by filtration, the reaction could be purified easily in an aqueous solution by liquid-liquid extraction, and the product DEET was high purity. This experimental efficiency is about 94-95%, purity (HPLC): 97-98%.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
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1. Diethylamine;Encyclopedia of Toxicology;2024