Affiliation:
1. State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Abstract
Abstract:
Scopolamine, as an anticholinergic agent, plays a regulatory role in the peripheral nervous
system. In this paper, 6,7-dehydrotropinone, which is the key intermediate of scopolamine, is synthesized
in moderate yield through [4+3] cyclization reaction and Barton deoxygenation reaction. This
route has good application prospects with mild reaction conditions, moderate yield, and simple operating
procedures.
Funder
Beijing Natural Science Foundation
National Key R&D Program of China
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
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