Synthesis of New Thiazolidinones and Thiazoles in Indole Series-Reference-Cited by-同舟云学术

Synthesis of New Thiazolidinones and Thiazoles in Indole Series

Published:2023-01 Issue:1 Volume:20 Page:11-17
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Benmohammed Abdelmadjid¹²,Vanelle Patrice³,Khanoussi Sofiane¹,Khoumeri Omar³,Kadiri Mokhtaria¹,Djafri Ayada¹,Terme Thierry⁴

Affiliation:

1. Laboratoire de Synthèse Organique Appliquée (LSOA), Département de Chimie, Faculté des Sciences Exactes et Appliquées, Université Oran1 Ahmed Ben Bella, BP 1524 El M’Naouer, Oran 31000, Algeria

2. Department of Chemistry, Faculty of Exact Sciences, University of Mascara, Mascara 29000, Algeria.

3. Laboratoire de Pharmaco Chimie Radicalaire, Aix Marseille Université, CNRS, ICR Institut de Chimie Radicalaire, UMR 7273, Faculté de Pharmacie, 27 Boulevard Jean Moulin-CS 30064, 13385 Marseille Cedex 05, France

4. Aix Marseille Université, CNRS, ICR Institut de Chimie Radicalaire, UMR 7273, Laboratoire de Pharmaco Chimie Radicalaire, Faculté de Pharmacie, 27 Boulevard Jean Moulin-CS 30064, 13385 Marseille Cedex 05, France

Abstract

Abstract: Recent findings confirm that thiosemicarbazones and thiazoles offer a wide range of biological properties. We report here the synthesis of two series of highly functionalized thiazole-derived compounds from the reactions of various indole-derived thiosemicarbazones with diethyl acetylenedicarboxylate and 4-bromophenacyl bromide. As a result, a series of new derivatives of thiosemicarbazone, thiazolidinone, and thiazole bearing an indole moiety was synthesized and developed in good yields.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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