Chiral NADH Model: Design, Synthesis, Asymmetric Reduction Reaction, and Fluorescence Characteristics

Author:

Wang Nai-Xing1,Xu Bao-Cai2,Wang Bo-Zhou3,Bai Cui-Bing1,Zhang Lei-Yang1,Yan Zhan1,Wu Yue-Hua1,Liu Ning3,Tomasic Vesna4

Affiliation:

1. Technical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, China

2. School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing 100048, China

3. State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi’an Modern Chemistry Research Institute, Xi’an 710065, China

4. The Faculty of Chemical Engineering and Technology, Faculty of the University of Zagreb, Zagreb 10000, Croatia

Abstract

Abstract: A new type of NADH model compound, which has six asymmetric carbon centers, has been synthesized by an efficient and convenient method. We used NADH models combined with enzymes in the asymmetric reduction. It was the first time that dehydrogenase combined with NADH models instead of inorganic catalysts, such as MgCl2, was used in the asymmetric reduction. Furthermore, the experimental results showed that the new NADH model has the strongest fluorescence emission properties compared to previously reported models.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3