The Synthesis of Amides from Benzoic Acids and Dicarbodiimides Under Catalyst-Free Conditions

Author:

Wu Fengtian1,Wu Ling1,Cui Chunna2,Yan Fangming3,Zeng Rong1,Sun Yijia1,Liu Xiuping1,Zhang Caihong1,Chen Yenan1

Affiliation:

1. Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices, Jiangxi Province Key Laboratory of Synthetic Chemistry, East China University of Technology, Nanchang 330013, People’s Republic of China

2. Fujian Provincial Key Laboratory of Featured Biochemical and Chemical Materials, Ningde Normal University, Ningde 352106, People’s Republic of China

3. Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices, Jiangxi Province Key Laboratory of Synthetic Chemistry, East China University of Technology, Nanchang 330013, People’s Republic of China

Abstract

Abstract: Amides are a critical class of widely distributed heterocycles in nature. The preparation of amides from benzoic acids and dicarbodiimides under catalyst-free conditions was reported. Various products were obtained in good to high yields. The model reaction could be scaled up to the gram-scale level. A reaction mechanism was proposed based on control experiments and relevant literatures.

Funder

Advanced Talents of the East China University of Technology

Foundation of Jiangxi Provincial Department of Science and Technology

Opening Fund Project of Fujian Provincial Key Laboratory of Featured Biochemical and Chemical Materials

Opening Project of Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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