Oxa-michael addition reactions of 3-hydroxy-2-azetidinones: synthesis of 1,3,4-trisubstituted-2-azetidinones
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Published:2021-06-10
Issue:
Volume:18
Page:
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Sharma Priyanka1,
Mann Maninderjeet Kaur1,
Bhargava Gaurav1ORCID
Affiliation:
1. Department of Chemical Sciences, I. K. Gujral Punjab Technical University, Kapurthala, Punjab 144 603, India
Abstract
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The manuscript describes a facile and efficient methodology for the synthesis of 1,3,4- trisubstituted-β-lactams by base mediated oxa-Michael addition reactions of 3-hydroxy-2-azetidinones with acetylenic esters under different reaction conditions. These functionalized 1,3,4-trisubstituted-azetidin-2-ones are useful organic synthons for the synthesis of various heterocyclic compounds having diverse pharmacological applications.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
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