Affiliation:
1. Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), DPSRU, Sector-3, Pushp Vihar, New Delhi, India
Abstract
:
The 1, 5-benzothiazepine derivatives are of particular interest for lead discovery since they have been found active against different families of targets.1,5-Benzothaizepines representatives of benzologs of 1,4-thiazepine and one of the three possible benzo-condensed derivatives, i.e. the 1,5-benzothiazepines are useful compounds in the drug research which has stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations. 1,5-Benzothiazepine and its derivatives exhibit diverse biological activities such as tranquilizer, antidepressant, antihypertensive, calcium channel blocker, antimicrobial, anticancer, antifungal, anthelmintic, anti-diabetic, amyloid imagining agents and anticancer agents. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing 1, 5-benzothiazepines moiety that could be better agents in terms of efficacy and safety.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
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