A Review: Synthesis and Pharmacological Profile of [1, 5]-Benzothiazepine

Abstract

: The 1, 5-benzothiazepine derivatives are of particular interest for lead discovery since they have been found active against different families of targets.1,5-Benzothaizepines representatives of benzologs of 1,4-thiazepine and one of the three possible benzo-condensed derivatives, i.e. the 1,5-benzothiazepines are useful compounds in the drug research which has stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations. 1,5-Benzothiazepine and its derivatives exhibit diverse biological activities such as tranquilizer, antidepressant, antihypertensive, calcium channel blocker, antimicrobial, anticancer, antifungal, anthelmintic, anti-diabetic, amyloid imagining agents and anticancer agents. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing 1, 5-benzothiazepines moiety that could be better agents in terms of efficacy and safety.