A new procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-one and octahydroquinazolinone derivatives catalyzed by SCMNPs@CA-EA-SO3H under solvent-free conditions

Abstract

Abstract: Catalyzed with SCMNPs@CA-EA-SO3H, as a green and heterogeneous solid acid catalyst, 3,4-dihydropyrimidin-2(1H)-one and octahydroquinazolinone derivatives were obtained in high-to-excellent yields and in short reaction times via the one-pot multi-component condensation of ethyl acetoacetate or dimedone, urea, and aldehyde compounds under solvent-free conditions. More importantly, the green catalytic system could be easily collected from the reaction solution utilizing an external magnet and reused for five runs with a negligible decrease in yields and reaction rate.