Cu-Catalyzed Cascade Reaction of Isoxazoles with Diaryliodonium Salts for the Synthesis of Acridines
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Published:2020-12-08
Issue:12
Volume:17
Page:944-950
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Zhu Shangrong1,
Lu Xuechen1,
Xu Qiuneng1,
Li Jian1,
Yan Shenghu1
Affiliation:
1. School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou, 213164, China
Abstract
A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade
reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted
and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has
gone through tandem double arylation and Friedel-Crafts reactions.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry