Synthesis, Design and Biological Evaluation of Antibacterial Activity of Novel Mixed Metal Complexes Derived from Benzoimidazolphenylethanamine and 6-Amino-N,N-dimethyluracil

Abstract

Benzoimidazolphenylethanamine (BPE) was synthesized through the condensation reaction of 1,2-phenyldiamine and L-phenylalanine. The new complexes were prepared from the reaction of 6- amino-N,N-dimethyluracil (ADU), benzoimidazolphenylethanamine and Cadmium (II), Tin (II), Copper (II) and Nickel (II) metal respectively. All new hybrid complexes were fully characterized by spectroscopic data of FTIR, UV-Visible electronic absorption, thermal analysis, X-ray powder diffraction studies and mass spectroscopy. Spectra analyses of the hybrid metal complexes showed the tetrahedral coordination of the ligands to the metal ions via the nitrogen atoms. The in vitro antibacterial activities of the hybrid complexes were assayed against four bacterial isolates namely, Micrococcus luteus, Staphylococcus aureus as Gram-positive bacteria, Pseudomonas aeruginosa and Escherichia coli as Gram-negative bacteria using the agar well diffusion method. Most of the tested isolates were sensitive to most metal hybrid complexes. The drug-likeness and bioactivity properties were calculated using Molinspiration Cheminformatics software.