Acyclic Aldehydo Sugars: 1,3-dimethyl-4,5-diamino Uracil as Recoverable
Carbonyl Protecting Group
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Published:2024-02
Issue:2
Volume:21
Page:213-215
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Fuentes-Rios D.1,
Doña M.1,
López-Romero J.M.1,
Rico R.1
Affiliation:
1. Dep. Química Orgánica, Universidad de Málaga, Málaga 29071, Spain
Abstract
Abstract:
1,3-dimethyl-4,5-diaminouracil has been used as an efficient protecting group for the carbonyl
moiety in sugars by the formation of the imine group. The protection reaction is carried out under
mild conditions, the yields are quantitative in most of the cases, and the protecting group is completely
recovered and reused. After per-acetylation, deprotection is accomplished at room temperature with
aqueous formic acid to produce acyclic acetylated sugars in good global yield.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry