Synthesis Memantine and Memantine Hydrochloride by Direct Amination of 1-Bromo-3,5-dimethyladamantane with Thiourea

Abstract

Abstract: Memantine hydrochloride (MH) is a first-line therapeutic drug approved by the US FDA for the management of moderate to severe Alzheimer's disease. This study involves the synthesis of memantine hydrochloride from 1-bromo-3,5-dimethyladamantane through a reaction with thiourea. The research results showed that the solvent reaction was propylene glycol (PG); the total time reaction was 5.5 hours, the temperature reaction in the first stage was 160oC and in the second stage was 80oC; the overall yield was 82.44%. The reaction intermediates were confirmed by the IR, MS,1HNMR, and 13C-NMR spectra.