Synthesis of Four Eugenol Metabolites
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Published:2021-05-04
Issue:5
Volume:18
Page:415-418
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Jia Xixi1,
Zhou Hao1,
Liu Xiwang1,
Li Jianyong1
Affiliation:
1. Key Lab of New Animal Drug Project of Gansu Province, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, 730050, China
Abstract
Four eugenol metabolites were concisely synthesized and their structures were confirmed by
1H-NMR, 13C-NMR and high-resolution mass (HR-MS). Among them, the synthesis of eugenol-β-Dglucuronide
(3) and eugenol sulfate (4) was reported for the first time. The successful synthesis of the
four eugenol metabolites provides a material basis for further metabolic study of prodrug aspirin eugenol
ester (AEE).
Funder
Natural science foundation of Gansu Province
CAAS
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry