Synthesis and Antibacterial Evaluation of Thiouracil Derivatives Contain-ing 1,2,4-Triazolo[1,5-a]Pyrimidine
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Published:2020-08-26
Issue:
Volume:17
Page:
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Cui Penglei1,
Zhang Di2,
Guo Xiumin1,
Ji Shujing1,
Jiang Qingmei1
Affiliation:
1. College of Science, Hebei Agricultural University, 071001 Baoding, China
2. College of Food Science and Technology, Hebei Agricultural University, 071001 Baoding, China
Abstract
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A series of new thiouracil compounds containing 1,2,4-triazolo[1,5-a]pyrimidine were designed and synthesized. The in vitro antibacterial activities of the new compounds against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis were tested. The results showed that some of the new compounds had strong inhibitory activities against the tested bacteria. At the concentration of 50 μg/mL, the compound 12d had broad and the highest inhibitory activity with the 100% inhibition against the three tested strains, the same as norfloxacin which was used as the control.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry