Affiliation:
1. Department of Chemistry, Faculty of Art and Sciences, Recep Tayyip Erdogan University, 53100, Rize, Turkey
Abstract
A series of 1,2,4-triazole and 1,2,4- thiadiazole derivatives were prepared starting from ethyl
4-(3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzoate. Firstly, both ethyl ester groups were
simultaneously transformed into hydrazide groups, then into thiosemicarbazide groups using both microwave-
assisted and conventional methods. The latter products were interacted with NaOH and
H2SO4 to form ring assemblies containing two 1,2,4-triazole and 1,3,4-thiadiazole fragments, respectively.
Antioxidant activities of the synthesized compounds were determined with CUPRAC, ABTS,
and DPPH assays. Most of the compounds showed significant antioxidant activity and especially, compound
3 exhibited very good SC50 value for DPPH method and compound 3, 4a, 5a exhibited very high
scavenging activity to the ABTS method. In addition, the in silico analysis was carried out with the
synthesized derivatives to understand the mode of interaction with superoxide dismutase (SOD) and
human tyrosine kinase using docking protocols in order to find out the most active antioxidant drug
having high inhibitory activity in cancer.
Funder
Scientific and Technical Research Council of Turkey
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献