Synthesis and Evaluation of Isatin Derivatives as Antifungal Agents-Reference-Cited by-同舟云学术

Synthesis and Evaluation of Isatin Derivatives as Antifungal Agents

Published:2020-02-19 Issue:3 Volume:17 Page:199-205
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Dawar Monika¹,Utreja Divya¹,Rani Ritu²,Kaur Komalpreet¹

Affiliation:

1. Department of Chemistry, Punjab Agricultural University, Ludhiana-141004 (Punjab), India

2. Department of Plant Pathology, Punjab Agricultural University, Ludhiana-141004 (Punjab), India

Abstract

Various types of isatin derivatives were synthesized by reacting isatin with different reagents viz substituted acetophenones, sodium nitrate, hydroxylamine hydrochloride and hydrazine hydrate. Characterization of the synthesized compounds was done by using various spectral techniques such as IR, 1HNMR, 13CNMR, elemental analysis and mass spectrometry. Synthesized compounds were further evaluated for their antifungal activity against Helminthosporium oryzae, Rhizoctonia solani and Fusarium moniliforme using poison food technique. 3-(2-Oxo-2-phenylethylidene) indolin- 2-one showed significant mycelium inhibition against all tested rice fungi.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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